Hypopigmented patches

• Hypopigmented patches develop when pigment-producing cells (melanocytes) die or cease melanin production.

• Affected areas of the skin become lighter or white, but the exact cause of melanocyte failure or death remains unclear.

• Potential contributing factors include:

  • An autoimmune disorder affecting the immune system
  • Genetic predisposition (family history)
  • Triggering events, such as stress, severe sunburn, or skin trauma (e.g., chemical exposure)

Mechanism of Action:

• Stimulate the activation, migration, and/or proliferation of melanocytes into hypopigmented areas at the dermal-epidermal junction (DEJ), targeting the shallow dermis depth.
• Mechanical trauma from microneedling encourages melanocyte migration from pigmented to unpigmented areas.
• Microneedling may enhance the number of pigment cells and promote increased pigment production.
• Research suggests that six or more treatment sessions may be required to observe noticeable improvements.

Ebrahim et al. J Cosmet Dermatol. 2020;00:1–8